Plasminogen activators promote excitotoxicity‐induced retinal damage
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چکیده
منابع مشابه
Plasminogen activators promote excitotoxicity-induced retinal damage.
Increased levels of extracellular l-glutamate have been suggested to play a role in retinal damage in a number of blinding diseases such as glaucoma and diabetic retinopathy. Although glutamate can cause retinal damage in part by hyperstimulating its receptors ("excitotoxicity"), the downstream events that lead to retinal damage are poorly understood. In this study, we injected kainic acid (KA)...
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To investigate the role of tissue plasminogen activator (tPA) in retinal damage, tPA-deficient and wild-type mice were employed. Two different retinal neuron insult models were used in the present study. One is an excitotoxin-treated retinal model, created by direct intravitreal injection of glutamate analogs, NMDA or kainic acid (KA), and the other is an ischemia-reperfusion model induced by t...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2005
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.04-3403com